2Ophthalmologist, MD, Ophthalmology Department of Universal Eye Disorder Hospital, Malatya, Turkey
3Prof., MD, Biochemistry Department of Fırat University, Medicine School, Elazıg, Turkey
4Assistant Prof, MD, Immunology Department of Onsekiz Mart University, Medicine School, Çanakkale, Turkey
5Assistant Prof., MD, Ophthalmology Department of Fırat University, Medicine School, Elazıg, Turkey DOI : 10.37844/glauc.cat.2021.16.10 Purpose: To evaluate the levels of salusin-beta (?-Sal) in the serum in patients with open-angle glaucoma.
Materials and Methods: This pilot work was designed as an institutional controlled comparative clinical study. The serum ?-Sal levels of age and sex-matched 20 healthy volunteers as controls (Group 1), 15 patients with normal-tension glaucoma (NTG) (Group 2), 18 patients with pseudoexfoliative glaucoma (PXG) (Group 3) and 26 patients with primary open-angle glaucoma (POAG) (Group 4) were measured with the enzyme-linked immunosorbent assay (ELISA) method.
Results: There was no statistically signifi cant difference concerning age and gender among the groups (p>0. 05). The mean serum ?-Sal levels in Group 1, Group 2, Group 3 and Group 4 were 4977.02±3741.44 pg/mL; 1086.57±253.41 pg/mL; 1044.98±268.80 pg/mL and 868.32±181.78 pg/mL, respectively. Although the mean ?-Sal levels in all glaucoma groups seem numerically lower than the control group, there was no statistically signifi cant difference between the serum ?-Sal concentrations of the study groups (p>0.05).
Conclusion: These findings suggest that serum salusin-? levels are not different among various open-angle glaucoma types. However, theoretically, ?-Sal may contribute to the pathogenesis of glaucoma and may play a neuroprotective hormone in glaucoma. Further studies with large patient population are required to say whether ?-Sal plays a role in the pathogenesis of glaucomatous optic neuropathy.
Keywords : Open-angle glaucoma, Salusin beta, Serum level